Gluten sensitivity and celiac disease are reactions to proteins found in wheat gluten.
What it Measures
The Celiac Profile measures several antibodies: IgG and IgA to gliadin, a protein found in wheat gluten – which, when elevated indicate gluten sensitivity or possibly celiac disease. IgA antibodies to tissue transglutaminase are also measured, and when elevated strongly suggest celiac disease.
With gluten sensitivity, the body produces antibodies to wheat proteins, which can inflame the gut lining and produce symptoms. The effects of gluten sensitivity are often unpleasant, but unlike celiac disease, do not cause permanent damage. Gluten sensitivity was recently recognized as a unique condition, separate from wheat allergy and celiac disease, by the International Celiac Symposium in 2011.
In celiac disease, eating gluten triggers the immune system to attack and damage the villi (small finger-like projections) of the small intestine, thereby seriously impairing the ability to absorb nutrients from food. Celiac disease is considered an autoimmune disease and is associated with: autoimmune thyroiditis, Addison’s disease, Sjogren’s syndrome and autoimmune liver disease.
Why Test Celiac Profile?
The Celiac Profile tests for gliadin antibodies, to determine if gluten sensitivity is the problem – along with tissue transglutaminase antibodies to diagnose for celiac disease.